App State overwhelmed Charlotte 34-11 in a Week 1 contest, with the Mountaineers controlling most of the game through strong second and third quarter performances. App State quarterback AJ Swann led the offensive attack with 368 passing yards. The Mountaineers scored 17 points in the second quarter and 10 in the third to build a commanding lead before coasting to victory.

Charlotte managed only a field goal in the first quarter and was shut out through the third period before scoring eight points in the fourth quarter. The 49ers' offensive struggles were evident throughout, with key penalties stalling drives and defensive pressure from App State proving decisive in critical moments.

App State's defense made pivotal plays down the stretch, with multiple high-impact defensive sequences in the fourth quarter. The victory came comfortably for the Mountaineers, who covered the 3-point spread in decisive fashion. The game finished well under the 49-point over/under, with the two teams combining for 45 total points.