Western Kentucky overwhelmed North Alabama 55-6 in Week 1 play. The Hilltoppers controlled the contest from start to finish, scoring 14 points in the first quarter and exploding for 28 in the second quarter to build an insurmountable lead.

WKU's offense was particularly dominant in the second quarter, with quarterback Maverick McIvor connecting on three touchdown passes. McIvor threw a 78-yard TD to K.D. Hutchinson, followed by a 20-yard score to Jairus Mack and a 14-yard touchdown to Matthew Henry. John Cannon converted all extra points.

North Alabama managed only a field goal in the opening quarter and was held scoreless for the remainder of the game. Destin Wade led the Lions' ground attack, including a 22-yard run in the third quarter, but the offense never found rhythm against the Hilltoppers' defense.

WKU added three points in the third quarter and 10 more in the fourth to cruise to victory. The home team covered the 27.5-point spread with ease. Rodney Tisdale Jr. led WKU's passing attack with 94 yards, while Quincy Burroughs had 9 receptions and La'Vell Wright rushed 9 times.